Warszawski Uniwrsytet Medyczny

WARSZAWSKI UNIWERSYTET MEDYCZNY (MEDICAL UNIVERSITY OF WARSAW) AS A PUBLIC CHARITY REFERS ITS ACTIVITIES TO EDUCATIONAL GOALS. IT'S MISSION IS TO EDUCATE STUDENTS FOR PRACTICING MEDICINE, DENTISTRY, NURSING, MIDWIFERY, PHYSIOTHERAPY AND PHARMACY. THE MAIN ACTIVITIES ARE CONDUCTED AT FIVE ACADEMIC FACULTIES.

NCBR168 EPILEPSY AFFECTS 1 PERCENT OF THE WORLD'S POPULATION AND 6 MILLION PEOPLE IN EUROPE. THE ESTIMATED TOTAL COST OF 20 BILLION EUR IN EUROPE IN 2014 MAKES EPILEPSY A SIGNIFICANT SOCIOECONOMIC BURDEN. DESPITE GREAT PROGRESS IN THE MANAGEMENT OF EPILEPSY AND INCREASING NUMBERS OF ANTIEPILEPTIC DRUGS, 30-40 PERCENT OF EPILEPSY PATIENTS ARE REFRACTORY TO ALL AVAILABLE MEDICATIONS. MOREOVER, IN CHILDHOOD EPILEPSY IS A CAUSATIVE FACTOR OF PSYCHIATRIC AND BEHAVIOURAL COMORBIDITIES, INCLUDING DEVELOPMENTAL DELAY AND AUTISM SPECTRUM DISORDER. IN SPITE OF MULTIPLE TRIALS NO RELIABLE BIOMARKER OF EPILEPSY DEVELOPMENT HAS BEEN IDENTIFIED. THERE ARE NO STUDIES ON BIOMARKERS OF DRUG-RESISTANCE OR EPILEPSY RECURRENCE AFTER THE DRUG WITHDRAWAL. EPIMARKER IS A FIRST PROJECT, CARRIED OUT IN HUMANS, WHICH IS GOING TO EXAMINE IN PROSPECTIVE WAY CLINICAL, ELECTROENCEPHALOGRAPHIC AND MOLECULAR BIOMARKERS TO PRODUCE AN INTEGRATIVE TOOL USEFUL IN EVERYDAY DIAGNOSIS AND TREATMENT OF EPILEPSY IN CHILDREN TO PREVENT THE DEVELOPMENT OF DRUG-RESISTANT EPILEPSY AND ITS BEHAVIOURAL COMORBIDITIES AS MENTAL RETARDATION AND AUTISM. THE SET OF MOLECULAR BIOMARKERS WILL BE DETERMINED BY QUANTITATIVE TRANSCRIPTOMIC AND PROTEOMIC STUDIES AND VALIDATED IN REPROGRAMMED CELLULAR MODELS. THE STUDY COMBINES THE EFFORTS OF POTENT RESEARCH CENTRES IN POLAND AND INCORPORATES THE NOVEL DISCOVERIES OF BIOTECHNOLOGY, ENGINEERING AND INFORMATICS.

NCBR128 THE PROPOSED PROJECT IS THE WORLD'S FIRST RESEARCH PROJECT BASED ON THE USE OF ALLOGENEIC HUMAN SKIN MATRIX ADM SEEDED WITH ALLOGENEIC STEM CELLS AND ON A DRESSING OF AUTOLOGOUS CELLS TAKEN FROM THE AREAS OF REVERTANT MOSAICISM IN THE EPIDERMOLYSIS BULLOSA TREATMENT. THE USEFULNESS OF A NOVEL ADM DRESSING FILLED WITH ALLOGENEIC STEM CELLS IN THE TREATMENT OF DEEP BURN WOUNDS AND LEG ULCERS WILL BE ALSO CONFIRMED; HERE, THE NOVEL DRESSING WILL ACT AS A SKIN GRAFT FILLING TISSUE DEFECTS AND AN ACTIVE DRESSING ALLOWING FOR THE EPITHELIALIZATION OF THE WOUND. THE PROJECT INCLUDES THE FOLLOWING RESEARCH TASKS: 1. PREPARATION OF THE HUMAN SCAFFOLD; 2. PREPARATION OF THE DRESSINGS; 3. DEVELOPMENT OF A STERILIZATION METHOD FOR THE BIOLOGICAL DRESSING FROM THE HUMAN MATERIAL; 4. DEVELOPMENT OF THE CLINICAL STUDY PROTOCOL AND CONDUCTING PATIENTS' QUALIFICATION AND RECRUITMENT TO CLINICAL STUDIES; 5. IN VITRO STUDIES OF THE STEM CELL-SEEDED SCAFFOLD; 6. CLINICAL STUDIES ON THE EFFECTIVENESS OF THE BIOLOGICAL DRESSING FROM THE HUMAN MATERIAL CONDUCTED ON 100 PATIENTS; 7. STUDIES ON REVERTANT MOSAICISM IN EB PATIENTS; 8. ANALYSIS OF ADHESION MOLECULES OF THE DERMAL-EPIDERMAL BORDER AND PROTEINS INVOLVED IN THE WOUND HEALING PROCESS IN SKIN BIOPSIES TAKEN FROM THE HEALED AREAS. THE FINAL PHASE OF THE PROJECT WILL BE DEDICATED TO THE PREPARATION FOR THE IMPLEMENTATION OF THE INNOVATIVE PRODUCT.

FS151 THE PROJECT IS FOCUSED ON THE DEVELOPMENT OF DIDACTICS USING THE SIMULATION METHOD, IMPLEMENTED IN A MODERN, MULTI-PROFILE MEDICAL SIMULATION CENTER. THE AIM OF THE PROJECT IS TO INCREASE THE EFFICIENCY AND QUALITY OF PRACTICAL TEACHING OF STUDENTS IN MEDICAL FACULTIES (MEDICINE, MEDICINE AND DENTISTRY, NURSING AND MIDWIFERY). THE PROJECT IS ORIENTED AT THE DEVELOPMENT OF DIDACTICS BY MEANS OF THE SIMULATION METHOD, PERFORMED IN A MODERN, MULTI-PROFILE MEDICAL SIMULATION CENTRE. THE PROJECT WILL ENABLE THE PURCHASE OF ALL NECESSARY EQUIPMENT MEETING THE STANDARDS FOR THIS TYPE OF CENTRE (MEDICAL SIMULATION CENTRE), INCLUDING MEDICAL AND DIDACTIC APPARATUS, AUDIO-VIDEO INFRASTRUCTURE OR FURNITURE. NON-INVESTMENT ACTIVITIES, SO-CALLED 'SOFT' TRAINING, ARE ALSO AN IMPORTANT PART OF THE PROJECT. THE ABOVE ACTIVITIES WILL ENABLE STUDENTS TO BECOME BETTER ACQUAINTED WITH THE HOSPITAL ENVIRONMENT PRE-CLINICALLY AND WILL COMPLEMENT CLINICAL CLASSES WITH THE POSSIBILITY OF PRACTICALLY PERFORMING THE ABOVE-MENTIONED HIGHLY SPECIALISED PROCEDURES, IN PARTICULAR - INVASIVE ONES.

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